Diabetic neuropathy is one very common complication of diabetes mellitus, in which temporary or permanent damage of the nervous tissue occurs as a result of a reduction in blood flow and high sugar levels in the blood. Symptoms appear 10 to 20 years after diabetes is diagnosed and approximately 50% of patients with diabetes develop neuropathy.

Under the clinical viewpoint, neuropathy can be classified in peripheral neuropathy and autonomic neuropathy; although both disorders frequently develop together in a combined form (diabetic polyneuropathy).

Peripheral neuropathy can affect the cranial nerves or those of the vertebral column and their ramifications; and its the type of nervous injury that begins with pain and intermittent tingling in the extremities, specially in feet; in more advanced stages the pain becomes more intense and constant, and finally it develops into a painless neuropathy which increases the risk of severe tissue injuries . The most frequent more symptoms are: paresthesia, tingling sensation, cramps, tumefaction, burning sensation, acute or stinging pain in the extremities, loss of balance, and others.

Autonomic neuropathies affect the nerves that regulate vital involuntary functions, including the cardiac muscle, smooth muscles and glands. The consequences of the autonomic neuropathy are: perspiration, orthostatic hypotension, neurogenic arthropathy, gastroparesis, diarrhea, constipation and sexual impotence, among others.

The management of a diabetic patient and his complications are extremely complex because it is a chronic and degenerative disease that practically affects to all human biological system. Most of the conventional treatments which are indicated at the moment alleviate the pain and may control some of the associated symptoms but the process is usually progressive.  Additionally, in many cases it does not stop the degeneration and, therefore, does not improve the patient's quality of life, thus the importance of alternative and complementary treatments.

The Systemic treatment includes superior plants that modulate the three axes of the survival triangle: Energy, Biological Intelligence and Organization, stimulating the endogenous tendency to auto healing, therefore, maximizing gains in health and contributing to improve the clinical evolution of the patient, as well as his quality of life.

By means of a prospective, multicenter and descriptive study, the improvement of signs and symptoms associated with neuropathy -in 71% of the patients- has been demonstrated. The increase in quality of life was demonstrated in 90.4% of the patients and there was as well -in all the cases- an excellent tolerance to the treatment. On the other hand, the indirect effect that the prolonged conventional drugs use can cause, such as: somnolence, ataxia and/or hepato-toxicity, among others, were avoided .

The herbal combinations formulated under the optics of the Systemic Medicine must be considered as a first choice treatment, in the cases diabetes cases with or without neuropathy.